Artefill is a dual-acting wrinkle filler which is comprised of a combination of precision-filtered microspheres and purified bovine collagen. First, the collagen in Artefill visibly corrects the wrinkles then the microspheres provide the support your skin needs for long-lasting, natural feeling wrinkle correction. Artefill is specifically designed to correct facial wrinkles and the creases around the mouth known as the nasolabial folds.