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Life Extension Indole 3 Carbinol/Reveratrol 60 Capsules
MMH ID: 26719; Brand: Life Extension; Model No: 00654

Life Extension Indole 3 Carbinol/Reveratrol 60 CapsulesMouse-over to zoom; click to expand

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60 capsules

It is a sad fact that the very hormones we need to stay young can cause adverse effects as we age. Consumption of cruciferous vegetables, however, can favorably alter one's hormone profile.

Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division. For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone. Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals. Human studies support the beneficial role of I3C in positively altering estrogen metabolism. Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.

The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.

Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division. Extracts from rosemary enhance liver metabolism of estradiol and estrone, inhibits the formation of DNA adducts, and have been shown to impede estrogen-induced growth promotion in certain tissues.

Based on a growing body of evidence that cruciferous vegetable extracts (in addition to I3C) provide bountiful health benefits, Life Extension has reformulated its I3C supplements to more closely resemble what one would obtain from a vegetable-rich diet.

For those weighing less than 160 pounds, just one capsule per day of Dual-Action Cruciferous Vegetable Extract with Resveratrol provides optimal potencies. Those weighing over 160 pounds should consider taking one capsule twice a day.

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2. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3. J Natl Cancer Inst. 1997 May 21;89(10):718-23.
4. Cancer Detect Prevent. 2004;28:72-9.
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6. Mol Cancer Ther. 2003 Oct;2(10);1045-52.
7. Carcinogenesis. 1998 Oct;19(10):1821-7.
8. Carcinogenesis. 1995 Sep;16(9):2057-62.

Supplement Facts

Serving Size 1 capsule

Servings Per Container 60

Amount Per Serving

Broccoli (Brassica oleracea l.) Super Concentrate

400 mg

Extract (plant and sprouts [standardized to


4% glucosinolates (16mg)]


Watercress (Nasturtium officinale) 4:1 Extract (leaf)

100 mg

Indole-3-Carbinol (I3C)

80 mg

Rosemary (Rosmarinus officinalis) Extract (leaves)

50 mg

[standardized to 20% diterpenic compounds


(10 mg) and providing carnosic acid/carnosol]


Resveratrol [from Red Grape (Vitis vinifera) Extract

20 mg

(whole fruit) and Polygonum cuspidatum Extract (root)]

DIM (Di-indolyl-methane)

14 mg

Other ingredients: gelatin, magnesium stearate, maltodextrin, rice flour, titanium dioxide.

This product contains NO wheat, yeast, gluten, corn, or dairy. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.

Dosage and Use

One capsule daily for individuals weighing up to 160 pounds.

Those weighing over 160 pounds, take two capsules daily.

This product can be taken with or without food.


May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac®), or proton-pump inhibitors (e.g. Nexium®), as these drugs may impede the conversion of I3C to active metabolites.

Related Keywords

Antioxidant, Cruciferous, Vegetables

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