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Life Extension Cognitex W/O Preg & Neuroprotection Complex 90 Caps
MMH ID: 26804; Brand: Life Extension; Model No: 00805

Life Extension Cognitex W/O Preg & Neuroprotection Complex 90 CapsMouse-over to zoom; click to expand

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90 capsules

Cognitex has been reformulated and changed from a softgel to a hard capsule to take advantage of new developments and ingredients for cognitive health. The previous Cognitex formulas provided premium levels of phospholipid nutrients (GPC and PS), vinpocetine and pregnenolone (option). This has been maintained while adding “next generation” nutrients and more vinpocetine for advanced brain protection.

More Protection Against Free Radicals

The brain is a highly active organ that produces high levels of free radicals from normal metabolism. These free radicals can bombard the fatty membranes of neurons and other brain cells causing premature loss of function. Cognitex contains a number of phytonutrient-based antioxidants that work best in a lipid (fat) rich environment like the brain.

Ingredients that work hard for you

While antioxidant nutrients provide essential free radical protection, many have limited capacity once they have spared an electron to balance a free radical. Cognitex now contains a novel rosemary extract that is rich in carnosic acid, which provides multistep protection against free radicals in a process called the carnosic acid cascade. At each step of free radical interaction a new compound is formed, which in turn is a powerful antioxidant in itself.

Bioavailable to the brain

Nutritional support for the brain is more challenging as a barrier called the blood-brain barrier keeps out toxins but also competing nutrients and drugs. Cognitex contains the grape seed extract Leucoselect® Phytosome™. By pairing one molecule of proanthocyanidins from grape seed extract with two molecules of phosphatidylcholine from soy lecithin in the Phytosome™, the uptake and distribution to target tissues of the grape seed polyphenols is enhanced.

Once in the brain, the polyphenols trap dangerous hydroxyl free radicals that turn fat rancid. These fats make up the outer lipid membrane of trillions of brain cells. These polyphenols also protect blood circulation and oxygen flow to the brain by improving the tone and elasticity of blood vessels.

Molecular size matters

High level of procyanidins from grape seed extract does not ensure an extract is going to have a beneficial effect on the body. Polyphenols with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™ contains smaller size molecules for advanced therapeutic activity as the larger molecules are discarded during the extraction process.

A difference you can feel

Taking dietary supplements can often be an act of faith as we often cannot feel what they are doing. Cognitex contains GPC and phosphatidylserine that improve neural function at the functional level over time. New to Cognitex is the patented, nonstimulant phytonutrient called Sensoril®. Sensoril® is a proprietary standardized extract of ashwagandha, also know as “Indian ginseng”, and used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue. Advanced extraction practices now allows for a highly concentrated yet balanced brain nutrient. The effects can often be felt immediately with greater alertness and focus but without the jitteriness of stimulants.

Mind your brain and body

Sensoril® also helps modulate the stress response resulting in cortisol excretion. Stress can be very damaging to the brain, especially memory function, and cortisol stimulates the body to release sugar (glucose) into the bloodstream. Elevated levels of glucose can accelerate aging and increase fat storage leading to weight gain, especially in the abdomen. In addition, the stress-modulating abilities of Sensoril® can help stress overeaters especially when it comes to carbohydrate cravings.

Advanced and safe inflammation protection

Cognitex now contains a new NeuroProtection Complex designed to provide highly concentrated standardized extracts of hops, ginger and rosemary – known anti-inflammatory nutrients.

IsoOxygene® is a new phytonutrient derived from the hops plant, that is beginning to be used in nutritional formulas in high dosages for inflammatory conditions. Cognitex uses a lower dose to address the low-grade inflammation occurring in the brain. How IsoOxygene® stands out from a myriad of anti-inflammatory compounds, including drugs, is that it is highly selective to COX-2 inhibition versus COX-1. The COX-2:COX-1 ratio for IsoOxygene® is 30:1 compared to about 2:1 for the majority of botanical and drug COX inhibitors. Studies on IsoOxygene® are on-going to determine levels of 5-LOX inhibition.

Circulation Is Key To Memory

Brain cells such as neurons are fed by blood vessels. Some of these microcapillaries can be so small that red blood cells carrying oxygen have difficulty passing through them. Neurons are the key structure for cognitive functions including memory. Vinpocetine enhances blood flow by dilating blood vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism by improving blood flow, increasing glucose and oxygen utilization by neurons and concentration of neurotransmitters involved in memory formation.

Supplement Facts

Serving Size 3 capsules

Servings Per Container 30

Amount Per Serving

Glyceryl Phosphoryl Choline (GPC)

600 mg


100 mg


20 mg

Phosphatidylcholine-Grape Seed Extract

150 mg

[Contains 50 mg of Leucoselect® Phytosome™


grape seed extract (95% polyphenols) bound to


100 mg of phosphatidylcholine from soy]


Sensoril® Ashwagandha (Withania somnifera) Extract

125 mg

(root and leaves) [standardized to 8% withanolide glycoside conjugates (10 mg) and 32% oligosaccharides (40 mg)]


Proprietary NeuroProtection Complex Blend

125 mg

IsoOxygene® Hops (Humulus Iupulus) Extract (aerial parts)

(standardized to 30% alpha and iso-alpha acids)


Ginger (Zingiber officinale) Extract (root)


(standardized to 5% gingerols by HPLC)


Rosemary (Rosmarinus officinalis) Extract (leaves)


(standardized to 20% diterpenic compounds)


Other ingredients: dicalcium phosphate, silicon dioxide, magnesium stearate, gelatin.

Leucoselect® is a registered trademark of Indena S.p.A. Phytosome™ is a trademark of Indena S.p.A. This product contains IsoOxygene®, manufactured by Pharmachem Laboratories, Inc. IsoOxygene® is a registered trademark. Sensoril® is protected under US Patents Nos. 6,153,198 and 6,713,092 and is a registered trademark of Natreon, Inc.

Dosage and Use

Take three capsules in the morning with or without food.

Some people may take three capsules twice daily or as recommended by a health care practitioner.


For some, taking this new Cognitex can cause hours of alertness so it may not be advisable to take near bedtime. Also, Sensoril® is an “adpatogenic” herb and like all adaptogens are effective by bringing balance within the body. Someone who is mentally exhausted and needs rest may find that initial use of this product may bring on a feeling of needing to sleep. This is normal and the body is responding to the need for rest. Continued use of the product will bring on mental reinvigoration.

Related Keywords

Brain, Memory, Inflammation, Congnitive

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