Product Description & Benefits:
The saikosaponins in Bupleurum Falcatum are mainly responsible for the plant's medicinal activities, but the pectins in this root extract also have immune system modulation activity. In vitro studies indicate saikosaponins have antiinflammatory effects by inhibiting arachidonic acid metabolism. Saikosaponin-d has immunoregulatory activity by promoting interleukin-2 production and receptor expression as well as modulating T-lymphocyte function.

This skin care active ingredient is made by a licensed, high-quality laboratory of skin care ingredients. Make Me Heal has partnered with leading laboratories and manufacturers of skin care ingredients to come up with the largest assortment of high-quality active ingredients that are effective for your skin. These ingredients are backed by scientific research and testing.

What's Do It Yourself (DIY) Skin Care?

DIY Skin Care is an emerging trend in the beauty world where consumers are taking control of their skin care regimen and are making their own home-based recipes of skincare products by combining scientifically proven active ingredients inside creams. DIY presents an opportunity to create affordable beauty products at your home and to try different ingredients to arrive at recipes that are the most optimal for your skin needs. You can use DIY to simply copy well-known, expensive creams and make your own cheaper home version, or to combine your favorite cream with an ingredient that you've found to be beneficial.

Directions For Use:
Each tube is enough for about 4 fl oz of cream or lotion at approximately 1% concentration (1 g in 120 mL cream) and can be combined with our other actives. The powder will not dissolve immediately but will release components slowly into the cream or lotion. Use in your favorite cream or add to our Canvas Base Cream or a Sea Kelp Bioferment base.

References:
Leung, Chung Yee; Liu, Liang; Wong, Ricky N. S.; Zeng, Yao Ying; Li, Ming; Zhou, Hua. (2005) Saikosaponin-d inhibits T cell activation through the modulation of PKC theta , JNK, and NF- kappaB transcription factor. Biochemical and Biophysical Research Communications, 338:1920-1927. Matsumoto, Tsukasa; Hosono-Nishiyama, Kanako; Guo, Ying-Jie; Ikejima, Takashi; Yamada, Haruki. (2005) A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of Bupleurum falcatum L. in murine B cell. International Immunopharmacology,5:1373-1386.

Kato, Masashi; Pu, Mei-Yi; Isobe, Ken-Ichi; Iwamoto, Takashi; Nagase, Fumihiko; Lwin, Tint; Zhang, Yue-Hua; Hattori, Taku; Yanagita, Noriyuki; Nakashima, Izumi. (1994) Characterization of the immunoregulatory action of saikosaponin-d. Cellular Immunology 159:15-25.

Park, Kwan Ha; Park, Jongmin; Koh, Dongsoo; Lim, Yoongho. (2002) Effect of Saikosaponin A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma. Phytotherapy Research, 16: 359-363.

Matsumoto, Tsukasa; Yamada, Haruki. (1995) Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2IIb. Journal of Pharmacy and Pharmacology 47:152-6."