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PMMA in FEB 2010


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Precise™ (PMMA) Implants: FACT SHEET

Over a century ago, Neuber(1) in Germany, reported what seems to be the first well documented attempt to correct soft tissue deficits, transferring fat harvested from the body, to the face of a patient. Due to the transient results that this popular technique produces, different products have been tested, and it wasn’t until the second half of last century that dependable products became available. Although many of them have proved to be safe, it is not uncommon to find different conditions associated to some of them, like silicone oil that has a long history of complications. The metrosexuality phenomenon, the aging generation of baby – boomers and the development of strong, effective drugs that make HIV infected patients live long, healthy lives, - among other things - have created the need for better products. We present Precise™, the last generation of PMMA, soft tissue filler well known by its safety and efficacy.

What is Precise™ ?
Precise is a state-of-the-art soft tissue filler, that comprises a range of concentrations of PMMA micro-particles suspended in saline solution based gel. It is used to replace and restore the tissue lost due to congenital or acquired soft tissue deficiencies. Precise can be used in the treatment of a wide spectrum of deficiencies ranging from slight superficial wrinkles to the large deficits found in pectus excavatum, Romberg’s syndrome, HIV induced lipoatrophy, large deficits caused by trauma, surgical or accident.

What is PMMA?
PMMA stands for polymethyl-methacrylate, the chemical name for a plastic that has been widely and safely used by the medical profession since 1936(2). This material has been implanted in humans for numerous purposes including the repair of skull defects, as a bone substitute, as the cement for fixing hip joint replacements, as artificial lenses and as dental implants. As of 2000, Passy et al reported that 180,000 treatments with PMMA have been administered to 60,000 patients (3) PMMA implantation can be used to improve the skin's contour and reduce depressions due to soft tissue loss, scars, injury or lines. The use of PMMA micro-spheres for the treatment of wrinkles and other minor dermal deficits was first reported more than 10 years ago (3,4,5)

Why Precise™?
Precise™ contains polymethyl-methacrylate (PMMA) micro-particles suspended in a newly patented revolutionary designed hydrogel. Injections of Precise™ induce the human body to produce networks of new organized tissue. The post treatment histological changes clearly show cell accumulation and development, growth of blood vessels, and formation of new elastin and collagen. This advance brings the powerful tool of Volumetric Plasty™ to the disposal of the reconstructive and cosmetic medical practitioner and their patients, a technique developed by the physicians at Clinic’estetica™ to enable the administration of implants at unprecedented levels of safety and efficacy. (6)
Precise™ is a revolution in compatibility. Almost all people are suitable for augmentation with PMMA. Precise’s, PMMA micro-particles are biologically inert and should be well tolerated by most (99.9%) people. Furthermore, the micro-particles in Precise™ are uneven and therefore are easier for the body to implant permanently as they function as individual ‘grappling hooks’, grasping the surrounding tissue, cementing itself in place; they are suspended in a new patented hydrogel making it more compatible than other PMMA based products such as Artecoll, and mostly pain free. Generally only the stick of the needle is felt. The PMMA in Artecoll is suspended in bovine collagen, a substance that creates serious allergic reactions in around 30% of the population, so all patients requesting Artecoll will require sensitivity testing and a 4 week observation period before receiving treatment.
Unlike other high volume implants such as Bio-Alcamid, Precise™ micro-particles become surrounded by the patient’s own collagen, blood vessels and other soft tissue components. Consequently, no non-vascular areas are created in the area of implantation meaning that if injury or infection should ever occur in or around the implant, the body’s natural defense mechanisms, and when necessary medications transmitted by the vascular system can reach and treat the affected area.
Several classes of dermal fillers are currently available including collagen based fillers, such as Zyplast and Cosmoderm, and hyaluronic acid based fillers, such as Restylane and Hylaform. However, these products offer only temporary solutions and these materials are macrophaged away (consumed by the body) in less than 6 months, and often only a couple of months after administration. Another dermal filler, Radiesse, comprises a suspension of calcium hydroxyapatite particles in glycerin and saline vehicle. Radiesse is estimated to last between 2 and 4 years but a high risk of subcutaneous nodules has been reported as some applications of this product.
Precise™, however, will not be macrophaged away (consumed by the bodies protective mechanisms) as its newly patented micro-particles are in excess of 62 microns (62 to 100) and thus not only represents a safe, effective and permanent solution but also the most cost effective choice.

Collagen Restylane™ Silskin ™ Sculptra ™
Made of Bovine, porcine or human Hyaluronic Acid Silicone oil Poly-lactic acid
Used for Wrinkles, lips Wrinkles, lips Wrinkles, lips Adding volume to cheeks and other facial areas
Tx needed 1 1 Many 3 or more
Skin testing Yes No No No
How long last 3-6 months 6 months to 1 year Permanent (!) Up to 2 years
Hypersensitivity +++ ++ ++++ +
Derivate of Cow, pig, human Rooster coombs, bacteria Synthetic Syntetic
Animal product? Yes Yes No No

Radiesse ™ Aquamid ™ BioAlcamid ™ Precise ™
Made of Calcium hydroxyapatite Polyacryl-amide Polyalkyl-imide Polymethyl-methacrylate
Used for Wrinkles, lips Small volume only Mid to large volume Small to large volume
Tx needed 1 1-2 1-2 1-3
Skin testing No No No No
How long last 2+ years Up to 2 years Permanent Permanent
Hypersensitivity + ++ + -
Derivate of Synthetic Synthetic Synthetic Synthetic
Animal product? No No No No


1. Neuber, F. Fettransplantation. Bericht uber die Verhandlungen der Dt Ges f Chir. Zentralbl Chir 1893, 22:66.
2. Vilar-Sancho, B. An old story: An ivory nasal implant. Aesthetic Plast Surg 11:157,1987.
3. Passy, S.: Novos usos do MPMMA-III Congresso Mundial da Sociedade Internacional de Cirurgia Estetica. Tokio, April 2000.
4. Passy, S.: Uso do Metacrill como agente reconstructor – I workshop internacional Metacrill. Rio de Janeiro, September 1998.
5. Lemperle, G. Kind, P.: Biocompatibility of Artecoll. Plast Reconstr Surg. 103: 338-340, 1999.
6. Casavantes, L. VolumetricPlasty: The use of soft tissue fillers for the reconstructive treatment of large soft tissue deficits in the body. 3er Congreso Mexicano de Dermatología Cosmética. Mexico City, June 2005.
7. Ersek, R. Beisang, A. Bioplastique: A New Textured Copolymer Microparticle Promises Permanence in Soft-Tissue Augmentation. Plast Reconstr Surg 1990.
8. Lemperle G, Ott H, Charrier U, Hecker J, Lemperle M.: PMMA microspheres for intradermal implantation. Part I. Animal Research Ann Plast Surg
9. Lemperle G, Pietz R, Lemperle M. First clinical experiences with Arteplast (PMMA-microspheres) injected beneath wrinkles and dermal defects. In Hiderer UT (ed), Plastic Surgery, vol II. Amsterdam, Elsevier Science Publishers. 539, 1992.
10. Lemperle G, Hazan-Gauthier N, Lemperle M. PMMA microspheres (Artecoll) for skin and soft tissue augmentation. Part II. Clinical investigation. Plast Reconstr Surg 96: 627-634, 1995.
11. Lemperle G, Gauthier-Hazan N, Lemperle M. PMMA microspheres Artecoll for long-lasting correction of wrinkles. Part III. Refinements and statistical results. Aesth Plast Surg 22:356-365, 1998.
12. Passy S. PMMA Implants: A new way to correct body defects without surgery. Int J Cosm Surg Aesth Derm. 5:2; 193-199, 2003.
13. Serra M, Oyafuso LK. Soft tissue augmentation with polymethylmethacrylate (PMMA) for correction of lipodystrophy related body fat atrophy. Antiviral Therapy 9(6): L31, 2004.
14. Pollock AG, Marsh HO PMMA, Treatment of pathological fractures using, methylmethacrylate to enhance strength of internal fixation. J. Kan Med Soc (United States) Sept 1978, 79 (9) p511-5


Comments (3)
andrenekaFrom: andreneka | 2010-02-02 19:27:56

when in febuary are you getting them causre i want them ASAP< PLEASE CONTACT ME SO I CAN KNOW THE NAME DOCTOR AND PRICE AND LOCATION> andrenekaw101@yahoo.com
carolann53922From: carolann53922 | 2009-11-10 08:25:41

Diaz- I got this info because I am getting the PMMA injections in feb and wanted to know what I was putting in my body- I asked-they gave unlike alot of places that want to fill u with crap they had nothing to hide an made me an informed pt- I was never told to keep this info to myself so ia m sharing it for the others like me that want the best option for butt injevtions.
diazFrom: diaz | 2009-10-26 22:55:17

I'm a bit curious, How did you get that info on "Precise" ? I thought that they had not told anyone what it is, because supposedly it's still under clinical trials.

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Member Details

Username: carolann53922
First Name: Carol
Location: RI, United States
Gender: F
Age: 29
Height: 5'5"
Ethnicity: Caucasian

Procedure Details

Date of Procedure: 02-28-2010
Results: 5 (Thrilled)
Weight: 149 lbs
Doctor Name: Dr. Morales My Profile
City of Procedure: Tijuana
Sate of Procedure: RI
Country: Mexico

Buttocks Augmentation, Lift, Implants:
Buttocks Augmentation Type: Buttock Implants

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